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CY cognition seminar: Computational modelling of neurotransmitter release

May 27 2022 | 14h00 - 15h30

Yulia Timofeeva (University of Warwick)

Online seminar (Zoom). 
Abstract:
Synaptic transmission provides the basis for neuronal communication. When an action-potential propagates through the axonal arbour, it activates voltage-gated Ca2+ channels located in the vicinity of release-ready synaptic vesicles docked at the presynaptic active zone. Ca2+ ions enter the presynaptic terminal and activate the vesicular Ca2+ sensor, thereby triggering neurotransmitter release. This whole process occurs on a timescale of a few milliseconds. In addition to fast, synchronous release, which keeps pace with action potentials, many synapses also exhibit delayed asynchronous release that persists for tens to hundreds of milliseconds. In this talk I will demonstrate how experimentally constrained computational modelling of underlying biological processes can complement laboratory studies (using electrophysiology and imaging techniques) and provide insights into the mechanisms of synaptic transmission.

Remote access:

https://cyu-fr.zoom.us/j/2222769563?pwd=NkdvYTM2dHdkejBrQnZiNXJWOUk5Zz09

Meeting ID: 222 276 9563
Secret code: 12312312

Details

Date:
May 27 2022
Time:
14h00 - 15h30

Venue

Zoom

Organiser

ETIS